Endocrine Abstracts

Devices for continuous glucose monitoring (CGM) measure interstitial glucose as a marker of changes in blood glucose. Although still lacking the accuracy of blood glucose meters, the CGM devices currently available have improved glucose control. The established technique of continuous subcutaneous insulin infusion (CSII) uses a portable electromechanical pump to mimic non-diabetic insulin delivery, infusing insulin at pre-selected rates. Essentially, a slow basal rate is achie...

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...

Introduction: Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroid metabolism constitute an important and a desirable element of scientific research in thyreology. Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and...

One of the important proangiogenic factors involved in the growth of normal and neoplastic tissues is vascular endothelial growth factor VEGF.Therefore we hypothesized, that serum VEGF concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum VEGF level. The study protocol was approved by the Ethical ...

The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25....

Introduction: Chronic autoimmune thyroid disease (ATD) or Hashimoto thyroiditis (HT) is one of the main thyroid diseases in pediatric age. HT characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function. Coeliac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects. At presents with a pathognomonic enter...

Continuous glucose monitoring (CGM) has highlighted the gap that exists between our expectations of tight metabolic control and the realities of actually achieving this, particularly during type 1 diabetes pregnancy. Longitudinal measurements indicate that despite overall ‘good’ HbA1c levels, pregnant women with type 1 diabetes spend 8 h/day with blood glucose levels above the recommended targets. New closed-loop (CL) or artificial pancreas approaches integrate insul...

Tumor growth is limited by its neoangiogenesis, which is dependent on dynamic balance beetween it’s activators and inhibitors. One of the most important antiangiogenic factor is endostatin. Therefore we hypothesized, that serum endostatin concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum endostatin level.<p...

Introduction: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common condition of the nervous system. It causes an overwhelming, irresistible urge to move the legs, mainly in the evening and night hours. It occurs in 7.2–10.0% of the population of western countries. Etiopathogenesis of RLS is not fully understood, but there is a hypothesis than an important role may play the imbalance between thyroid function and the dopaminergic system. The main ai...

Background and aims: The safety of thyroid surgery in terms of recurrent laryngeal nerve palsy and hypoparathyroidism was increasing in the last decade. In this study, we present a new method of tension-free thyroidectomy (TFT), which could be used to further decrease the complication rate after thyroidectomy.Patients and Methods: TFT is based on the medial approach to the recurrent laryngeal nerve (RLN) and the parathyroid glands after the division of i...